17 results found
    1. Neuroscience

    Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep

    Alan C Rupp, Michelle Ren ... Tiffany M Schmidt
    Daily fluctuations versus transient perturbations in environmental light influence behavior and physiology through distinct circuits.
    1. Neuroscience

    A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

    Kylie S Chew, Jordan M Renna ... Samer Hattar
    A single subpopulation of photoreceptors constitutes a shared node in the neural networks that regulate light-dependent maturation of the circadian clock and light-independent refinement of retinal ganglion cell projections to the brain.
    1. Neuroscience

    A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction

    William Thomas Keenan, Alan C Rupp ... Samer S Hattar
    A single class of neurons switches both its sensory detection and neurotransmission mechanisms to support transient or sustained physiological output.
    1. Neuroscience

    Light-dependent pathways for dopaminergic amacrine cell development and function

    Teona Munteanu, Katelyn J Noronha ... Tiffany M Schmidt
    Rods, not ipRGCs, are the major retinal photoreceptor impacting development of dopaminergic signaling in the retina.
    1. Neuroscience

    Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

    Ely Contreras, Jacob D Bhoi ... Tiffany M Schmidt
    Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
    1. Neuroscience

    Circuit mechanisms underlying embryonic retinal waves

    Christiane Voufo, Andy Quaen Chen ... Alexandre Tiriac
    Calcium imaging reveals spatiotemporal properties of correlated spontaneous activity in the embryonic retina and implicates a role for electrical and chemical synapses in generating the activity.
    1. Neuroscience

    Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations

    Andrew M Garrett, Abigail LD Tadenev ... Robert W Burgess
    Mammalian Dscams require different intracellular interactions in different cell types during neural circuit formation to promote self-avoidance.
    1. Structural Biology and Molecular Biophysics

    An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors

    Fei Ye, Yuxin Huang ... Mingjie Zhang
    Biochemical and structural studies uncover an unexpected mode of interaction, with unprecedented high affinity, between INAD scaffold and NORPA that is critical for Drosophila compound eye photo-transduction.
    1. Neuroscience

    The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

    Fugui Niu, Peng Han ... Sheng-Jian Ji
    The m6A reader YTHDF2 negatively regulates retinal ganglion cell dendrite branching through destabilizing its m6A-modified target mRNAs which control dendrite development and maintenance, and Ythdf2 conditional knockout in retina improves visual acuity and alleviates acute ocular hypertension-induced glaucoma in mice.
    1. Neuroscience

    A cell atlas of the chick retina based on single-cell transcriptomics

    Masahito Yamagata, Wenjun Yan, Joshua R Sanes
    A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.

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