A single subpopulation of photoreceptors constitutes a shared node in the neural networks that regulate light-dependent maturation of the circadian clock and light-independent refinement of retinal ganglion cell projections to the brain.
Melanopsin phototransduction targets distinct complements of transduction channels across intrinsically photosensitive retinal ganglion cell subtypes and does not require hyperpolarization-activated cyclic nucleotide-gated channels.
Christiane Voufo, Andy Quaen Chen ... Alexandre Tiriac
Calcium imaging reveals spatiotemporal properties of correlated spontaneous activity in the embryonic retina and implicates a role for electrical and chemical synapses in generating the activity.
Biochemical and structural studies uncover an unexpected mode of interaction, with unprecedented high affinity, between INAD scaffold and NORPA that is critical for Drosophila compound eye photo-transduction.
The m6A reader YTHDF2 negatively regulates retinal ganglion cell dendrite branching through destabilizing its m6A-modified target mRNAs which control dendrite development and maintenance, and Ythdf2 conditional knockout in retina improves visual acuity and alleviates acute ocular hypertension-induced glaucoma in mice.
A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.