90 results found
    1. Neuroscience

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng, Leah Boyer ... Tony Hunter
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj, Ricardo Mondragon-Gonzalez ... Rita CR Perlingeiro
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Immunology and Inflammation

    SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

    Cilia R Pothast, Romy C Dijkland ... Mirjam HM Heemskerk
    Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.
    1. Neuroscience

    Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    Milena Rmus, Mingjian He ... Matthew R Nassar
    Apparent age-related differences in learning are best accounted for by rapid decay of information in working memory, which is associated with levels of prefrontal glutamate.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes

    Carolina Ortiz-Cordero, Alessandro Magli ... Rita CR Perlingeiro
    The combined use of NAD+ with ribitol or ribose potentiates the rescue of α-dystroglycan functional glycosylation in FKRP-mutant patient-specific iPSC-derived myotubes, representing potential novel treatments for FKRP muscular dystrophies.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini, Roberta Schulte ... Martin W Hetzer
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
    1. Neuroscience

    Reconfiguration of functional brain networks and metabolic cost converge during task performance

    Andreas Hahn, Michael Breakspear ... Luca Cocchi
    Cognitive performance is supported by symbiotic metabolic and neuro-vascular responses in task-specific brain networks.
    1. Biochemistry and Chemical Biology

    Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB

    Sandra Olenic, Lim Heo ... Lee Kroos
    A novel mechanism of intramembrane protease regulation involves a protein blocking the active site of the enzyme.

Refine your results by:

Type
Research categories