625 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

    Ross T Lindsay, Sophie Dieckmann ... Andrew J Murray
    β-Hydroxybutyrate accumulates in the perfused rat heart during ischaemia, driven by flux through both HMGCS and SCOT, with implications for functional recovery.
    1. Cell Biology
    2. Neuroscience

    Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

    Lauritz Kennedy, Emilie R Glesaaen ... Johanne E Rinholm
    HCAR1 knockout mice are unable to initiate brain tissue repair after a hypoxic-ischemic injury.
    1. Cell Biology
    2. Medicine

    Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

    Felipe Freitas, David Attwell
    Renal capillary pericytes are a novel therapeutic target for reducing sustained reduction in renal blood flow ('no-reflow') after kidney ischaemia.
    1. Cell Biology
    2. Developmental Biology

    Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

    Kasmir Ramo, Koichi Sugamura ... Roger J Davis
    The kinase JNK is required in endothelial cells for the development of native collateral arteries.
    1. Cell Biology

    Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia

    Haoyang Wu, Peiyuan Lv ... Jiaji Lin
    An RNAi screen in mouse hippocampal neuronal cell line targeting epigenetic regulators revealed a novel neuroprotection of Prmt5 and uncovered its nucleus translocation feature and epigenetic mechanism in cerebral ischemia.
    1. Neuroscience

    NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

    Ruolin Zhang, Weibing Mao ... Zhiqiang Dong
    The combination of NSCs with NSC-derived exosomes ameliorated the injury of brain tissue including cerebral infarction, neuronal death, and glial scarring, and promoted the recovery of motor function.
    1. Cell Biology

    Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

    Fergus M O'Farrell, Svetlana Mastitskaya ... David Attwell
    Lack of reperfusion of cardiac capillaries, when an upstream artery is unblocked following heart attack, reflects contractile pericytes constricting capillaries and preventing blood flow, implying that cardiac pericytes are a therapeutic target for treating cardiac ischaemia.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

    Fangyan Wang, Xiujie Liu ... Wantie Wang
    Gut microbiota-derived gamma-aminobutyric acid is identified as a key metabolite that metformin protect from hepatic ischemia/reperfusion injury.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen, Christian Staehr ... Ebbe Boedtkjer
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke

    Paulo Wagner Pires, Scott Earley
    Acute hypoxia activates TRPA1 channels in cerebral artery endothelial cells to activate an early adaptive response to reduce tissue ischemic damage through vasodilation.

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