161 results found
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson, Ashley K Simon ... David J Katz
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin, Laurène Syx ... Edith Heard
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

    Hayden AM Hatch, Helen M Belalcazar ... Julie Secombe
    The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi, Zhen Shao ... Stuart H Orkin
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    A new role for histone demethylases in the maintenance of plant genome integrity

    Javier Antunez-Sanchez, Matthew Naish ... Jose Gutierrez-Marcos
    Plants reset chromatin marks during sexual reproduction to safeguard the stability of the genome.
    1. Genetics and Genomics

    Histone variants shape chromatin states in Arabidopsis

    Bhagyshree Jamge, Zdravko J Lorković ... Frédéric Berger
    In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.
    1. Biochemistry and Chemical Biology

    Diverse nucleosome Site-Selectivity among histone deacetylase complexes

    Zhipeng A Wang, Christopher J Millard ... Philip A Cole
    By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
    1. Cell Biology

    Searching for molecular hypoxia sensors among oxygen-dependent enzymes

    Li Li, Susan Shen ... Steven J Altschuler
    A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.

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