The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
Hayden AM Hatch, Helen M Belalcazar ... Julie Secombe
The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.
In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.
Zhipeng A Wang, Christopher J Millard ... Philip A Cole
By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.