11 results found
    1. Cancer Biology
    2. Cell Biology

    Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

    Kai Fu, Xin Sun ... Fengyi Wan
    Building on previous work (Fu et al., 2016), we demonstrate the critical role of Sam68 in orchestrating genotoxic stress-initiated NF-κB signaling in the colon and the pathophysiological relevance of Sam68-dependent NF-κB activation in colonic cell survival/recovery from extrinsic DNA damage.
    1. Cancer Biology

    Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

    Kai Fu, Xin Sun ... Fengyi Wan
    The nuclear protein Sam68 plays a role in the genotoxic stress-initiated "nuclear to cytoplasmic" activation of NF-κB and is involved in the development and survival of colon cancer.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa, Pamela Bielli ... Claudio Sette
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Robust and annotation-free analysis of alternative splicing across diverse cell types in mice

    Gonzalo Benegas, Jonathan Fischer, Yun S Song
    A robust computational pipeline for alternative splicing analysis is developed and applied to large-scale cell atlases, overcoming technical challenges and making results available for the scientific community to explore via public interactive browsers.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Stem Cells and Regenerative Medicine

    Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis

    Corentin Bernou, Marc-André Mouthon ... François D. Boussin
    1. Medicine

    Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice

    Jinjing Chen, Ruoyu Wang ... Jongsook Kim Kemper
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

    Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich
    RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
    1. Cancer Biology

    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

    Alessia Calcagnì, Lotte kors ... Andrea Ballabio
    Kidney-specific TFEB overexpression in transgenic mice closely recapitulates features observed in both TFEB- and TFE3-mediated human kidney tumors.
    1. Developmental Biology

    Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

    Hatice Duygu Saatcioglu, Motohiro Kano ... David Pépin
    Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.

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