10,080 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku, Jason B Muhitch ... Sharon S Evans
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro, Michelle N Yancoskie ... Yingguang Frank Chan
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber, Galia Tiram ... Ronit Satchi-Fainaro
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Environment determines evolutionary trajectory in a constrained phenotypic space

    David T Fraebel, Harry Mickalide ... Seppe Kuehn
    Experimental evolution shows that when selection acts on two traits constrained by a trade-off, the direction of phenotypic evolution depends on the environment.
    1. Structural Biology and Molecular Biophysics

    Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

    Assaf Elazar, Jonathan Weinstein ... Sarel Jacob Fleishman
    Deep sequencing analysis quantifies the hydrophobicity of the plasma membrane and provides restraints for structure modeling of receptor homodimers to atomic precision.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu, Jingjing Yu ... Xi Chen
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
    1. Microbiology and Infectious Disease

    Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA

    Tera C Levin, Brian P Goldspiel, Harmit S Malik
    Legionella pneumophila can be inhibited by its own antimicrobial, HGA (homogentisic acid), but its density-dependent resistance to HGA restricts the potential for self-harm.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai, Maria Trexler ... László Patthy
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Neuroscience

    THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

    Martin N Hebart, Oliver Contier ... Chris I Baker
    THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.

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