47 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model

    Deeptiman Chatterjee, Caique Almeida Machado Costa ... Wu-Min Deng
    Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.
    1. Cell Biology
    2. Developmental Biology

    Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish

    Prateek Arora, Shivali Dongre ... Mahendra Sonawane
    Polarity cascade initiated by aPKC in the periderm is transduced by adherens junction component E-cadherin to the basal epidermis during the development of zebrafish bilayered epidermis.
    1. Cell Biology

    Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

    Kalyn Kono, Shigeki Yoshiura ... Fumio Matsuzaki
    Par-complex-dependent cell polarity can be cell-autonomously conferred to non-polar Drosophila S2 cells, unveiling temporal patterns toward the cortical localization of Par-complex aggregates that include a meshwork containing unit segments.
    1. Cancer Biology
    2. Developmental Biology

    Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

    Julia Hatzold, Filippo Beleggia ... Matthias Hammerschmidt
    A Na,K-ATPase beta subunit can suppress basal cell carcinogenesis either via its osmoregulatory function to avoid hypotonic stress, or by promoting epithelial polarity and adhesiveness of basal keratinocytes from the overlying outer layer.
    1. Cell Biology

    Tumor elimination by clustered microRNAs miR-306 and miR-79 via noncanonical activation of JNK signaling

    Zhaowei Wang, Xiaoling Xia ... Tatsushi Igaki
    miR-306 and miR-79 selectively eliminate JNK-activated tumors, providing a new microRNA-based strategy against cancer.
    1. Cell Biology
    2. Developmental Biology

    Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen

    Maria Danielle Sallee, Melissa A Pickett, Jessica L Feldman
    During intestinal development, apical PAR complex proteins keep apical domains and junctions continuous between cells as they divide and elongate, and ultimately build a continuous functional tube.
    1. Cell Biology
    2. Developmental Biology

    Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2

    Juan Lu, Wei Dong ... Yang Hong
    When challenged by energetic stresses triggered by hypoxia and ATP inhibition, plasma membrane PI4P and PIP2 in cells undergo dramatic turnovers that have profound impact on many cellular processes including electrostatic PM targeting of numerous polybasic proteins.
    1. Developmental Biology
    2. Evolutionary Biology

    Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in the metazoa

    Miguel Salinas-Saavedra, Mark Q Martindale
    Even though the ctenophore Mnemiopsis leidyi develops polarized epithelial tissues, polarization is not mediated by the conserved mechanisms polarizing bilaterian and cnidarian epithelial cells.
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    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-autonomous immune response regulates stress signaling during hypertrophy

    Robert Krautz, Dilan Khalili, Ulrich Theopold
    The immune effector Drosomycin buffers stress signaling in hypertrophic salivary glands to inhibit their disintegration, detection by the cellular immune response, and promotes further overgrowth.
    1. Cell Biology
    2. Developmental Biology

    Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules

    Victoria G Castiglioni, Helena R Pires ... Mike Boxem
    PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.

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