5,110 results found
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Epidemiology and Global Health

    Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites

    Qianxi Feng, Eric Nickels ... Joseph L Wiemels
    Familial cancer clustering was significantly higher in US minority populations compared to those of US European origin, suggesting renewed need for a focus on family cancer predisposition in US Latinos, Blacks, and Asian/Pacific Islanders.
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova, Ward De Spiegelaere ... Linos Vandekerckhove
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear, Alex Diaz-Papkovich ... Ryan D Hernandez
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Chromosomes and Gene Expression

    Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

    Joshua M Galanter, Christopher R Gignoux ... Noah Zaitlen
    An epigenome-wide study shows that ethnic self-identification and genetically determined ancestry both make important independent contributions to DNA methylation levels.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar, Konstantina Georgiou ... Roland Foisner
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.
    1. Epidemiology and Global Health
    2. Medicine

    A systematic review of population-based studies on lipid profiles in Latin America and the Caribbean

    Rodrigo M Carrillo-Larco, C Joel Benites-Moya ... Antonio Bernabe-Ortiz
    In Latin America and the Caribbean the most common dyslipidaemia seems to be low HDL-cholesterol, and there has been little change in time for both mean levels and prevalence estimates.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

    Andrei Vovk, Chad Gu ... Anton Zilman
    Simple biophysical considerations explain the collective behavior of molecularly diverse complex protein assemblies that regulate transport between the nucleus and the cytoplasm in eukaryotic organisms.
    1. Plant Biology

    Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components

    Jeffrey C Berry, Mingsheng Qi ... Rebecca S Bart
    A method to reduce the noise present in field experiments by accounting for heterogeneity in field soils.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly, Eliya Bitman-Lotan ... Amir Orian
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.

Refine your results by:

Type
Research categories