1,406 results found
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

    Lukas P Feilen, Shu-Yu Chen ... Harald Steiner
    Biochemical studies in combination with computational modeling and molecular dynamics simulations reveal that the lipid bilayer promotes intramembrane proteolysis by stabilizing the enzyme-substrate complex and the protease active site.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

    Valeria Zoni, Rasha Khaddaj ... Stefano Vanni
    In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

    Josep Rizo, Levent Sari ... Milo M Lin
    Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The dimerization equilibrium of a ClC Cl/H+ antiporter in lipid bilayers

    Rahul Chadda, Venkatramanan Krishnamani ... Janice L Robertson
    Measuring the equilibrium dimerization of a polytopic membrane protein in lipid bilayers forms the basis of a new system for studying the physical forces that stabilize membrane protein association in membranes.
    1. Structural Biology and Molecular Biophysics

    State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

    Yein Christina Park, Bharat Reddy ... José D Faraldo-Gómez
    A theory is presented that explains why some ion channels tend to open in response to membrane stretching, which posits that channel closing is disfavored by the morphological energetics of the lipid bilayer, and increasingly so under lateral tension.
    1. Structural Biology and Molecular Biophysics

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira, Kranthi K Mandadapu ... David Chandler
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.
    1. Structural Biology and Molecular Biophysics

    A lipid bound actin meshwork organizes liquid phase separation in model membranes

    Alf Honigmann, Sina Sadeghi ... Richard Vink
    A combination of imaging experiments and computer simulations on a model lipid membrane integrate the 'picket fence' and 'raft' models, and suggest that the interplay between actin binding, lipid phase separation and curvature compartmentalize the membrane.
    1. Structural Biology and Molecular Biophysics

    Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters

    Xiaoyu Wang, Olga Boudker
    Substrate releasing or inhibitor binding on the intracellular side of a glutamate transporter homologue require movements of the transport domain through the lipid membrane, which undergoes adaptive deformations.
    1. Structural Biology and Molecular Biophysics

    Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals

    Chimari Jiko, Karen M Davies ... Christoph Gerle
    The transmembrane shape of the F1Fo ATP synthase monomer provides the molecular basis of high curvature at the ridges of mammalian mitochondrial cristae.

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