The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.
David Barneda, Joan Planas-Iglesias ... Mark Christian
An interaction between the brown fat protein CIDEA and the phospholipid phosphatidic acid is vital for the expansion of intracellular lipid droplets for energy storage.
Sven Kenjiro Vogel, Ferdinand Greiss ... Petra Schwille
Building on previous work (Vogel et al., 2013b), it is shown that myosin-driven actin filament rearrangements actively move, split or fuse individual lipid domains and change their overall shape.
Maria N Zanetti, Oscar D Bello ... Shyam S Krishnakumar
A model for synchronous neurotransmitter release suggests that when not in the presence of calcium ions, Synaptotagmin proteins form ring-like structures between the vesicle and plasma membrane that prevent spontaneous fusion.
C Keith Cassidy, Benjamin A Himes ... Peijun Zhang
An atomic model of the bacterial chemosensory array obtained through the synthesis of cryo-electron tomography and large-scale molecular-dynamics simulations reveals a new kinase conformation during signaling events.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
Seipin oligomers dynamically interact with small, nascent lipid droplets near the endoplasmic reticulum to convert them into larger, mature lipid droplets in a newly identified step of lipid droplet formation.
Intracellular growth of the bacterial pathogen Legionella pneumophila in the amoeba Dictyostelium discoideum implicates a bacterial fatty acid transporter as well as dynamic interactions of the distinct membrane-bound replication compartment with host cell lipid droplets.
