450 results found
    1. Cell Biology

    A critical role of VMP1 in lipoprotein secretion

    Hideaki Morishita, Yan G Zhao ... Noboru Mizushima
    The ER transmembrane protein VMP1 is important for release of lipoproteins from the ER membrane into the ER lumen for secretion.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

    Dmitry Ter-Ovanesyan, Tal Gilboa ... David R Walt
    A novel immunoassay for ApoB-100, the main protein component of lipoproteins, enables the development of methods to enrich extracellular vesicles from human plasma while depleting both lipoproteins and free proteins.
    1. Neuroscience

    Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    Jerome Robert, Emily B Button ... Cheryl L Wellington
    Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

    Christopher Icke, Freya J Hodges ... Ian R Henderson
    AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.
    1. Biochemistry and Chemical Biology

    GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

    Xuchen Hu, Ken Matsumoto ... Haibo Jiang
    The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
    1. Structural Biology and Molecular Biophysics

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Simon Mysling, Kristian Kølby Kristensen ... Michael Ploug
    Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.
    1. Genetics and Genomics
    2. Medicine

    A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

    Qingyuan Zhao, Jingshu Wang ... Daniel J Rader
    High-density lipoprotein (HDL) subfraction traits appear to have heterogeneous effects on coronary artery disease, giving support to the HDL function hypothesis.
    1. Cell Biology

    Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

    Xin Rong, Bo Wang ... Peter Tontonoz
    The enzyme Lpcat3 plays a unique role in the incorporation of arachidonic acid into membranes, which is required for the production of lipoproteins.
    1. Developmental Biology
    2. Neuroscience

    Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

    Marko Brankatschk, Sebastian Dunst ... Suzanne Eaton
    Yeast specific lipids promote the transport of lipid transfer protein (LTP) across the blood brain barrier to the neurons that regulate systemic insulin signaling.
    1. Microbiology and Infectious Disease

    Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

    Aaron G Wexler, Whitman B Schofield ... Andrew L Goodman
    The human gut bacterial lipoprotein BtuG binds vitamin B12 with femtomolar affinity, can remove vitamin B12 from human intrinsic factor, and is required for commensal fitness in the gut.

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