3,739 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

    Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
    ADeS, a novel deep learning approach for apoptosis detection, achieves 98% accuracy in vitro and in vivo while providing unprecedented insights into the spatial–temporal foundation of cell death.
    1. Chromosomes and Gene Expression

    Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

    Anand Ranjan, Vu Q Nguyen ... Carl Wu
    Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted photoactivation (PAPA)

    Thomas GW Graham, John Joseph Ferrie ... Xavier Darzacq
    Proximity-assisted photoactivation (PAPA) provides a new way to detect protein–protein interactions in single-molecule imaging of live cells.
    1. Cell Biology

    A novel live-cell imaging assay reveals regulation of endosome maturation

    Maria Podinovskaia, Cristina Prescianotto-Baschong ... Anne Spang
    A novel, inexpensive, easy-to-use method to analyse traffic along the endosomal pathway in mammalian cells shows that there is coordination between Rab conversion and acidification, but almost none between Rab conversion and recycling.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander, Juan Guan ... Orion D Weiner
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Cell Biology
    2. Plant Biology

    Live cell imaging of meiosis in Arabidopsis thaliana

    Maria A Prusicki, Emma M Keizer ... Arp Schnittger
    Live cell imaging and the in vivo dissection into distinct stages, called landmarks, represents a new methodology for analyzing meiosis in Arabidopsis and likely in other species as well.
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat, Mette Handberg-Thorsager ... Guillaume Balavoine
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Developmental Biology

    Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging

    Kevin Yueh Lin Ho, Rosalyn Leigh Carr ... Guy Tanentzapf
    A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.
    1. Cancer Biology

    Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

    Takahisa Maruno, Akihisa Fukuda ... Hiroshi Seno
    Genetic lineage tracing approach combined with live imaging visualized the functional stem cell activity of Doublecortin-like kinase 1+ cells within pancreatic cancer in vivo.
    1. Stem Cells and Regenerative Medicine

    Live imaging reveals the progenitors and cell dynamics of limb regeneration

    Frederike Alwes, Camille Enjolras, Michalis Averof
    Long-term live imaging reveals the dynamic cell behaviors and progenitor cells that underpin the regeneration of adult limbs in the crustacean Parhyale hawaiensis.

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