445 results found
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Point of View: The challenges faced by living stock collections in the USA

    Kevin McCluskey, Kyria Boundy-Mills ... Erich Grotewold
    Living stock collections provide invaluable resources to research communities, yet they face significant challenges.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

    Tim A Crombie, Stefan Zdraljevic ... Erik C Andersen
    Hawaiian Caenorhabditis elegans harbor high levels of genetic diversity that might represent the complex patterns of ancestral diversity in the species prior to human influence.
    1. Evolutionary Biology
    2. Plant Biology

    Environment as a limiting factor of the historical global spread of mungbean

    Pei-Wen Ong, Ya-Ping Lin ... Cheng-Ruei Lee
    After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    3D visualization of macromolecule synthesis

    Timothy J Duerr, Ester Comellas ... James R Monaghan
    Whole mount 3D visualization of macromolecule synthesis with light sheet fluorescence microscopy enables quantitative, multiscale analysis at the organ, cellular, and molecular levels of organization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

    Cassandra L Stowe, Thomas A Burley ... Martin A Pule
    Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

    Timothy M Errington, Alexandria Denis ... Brian A Nosek
    A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
    1. Cancer Biology

    Registered report: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kate Eaton, Wanwan Yang, Reproducibility Project: Cancer Biology
    1. Computational and Systems Biology
    2. Neuroscience

    A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

    Hannah Jones, Jenny A Willis ... Giorgio F Gilestro
    Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
    1. Neuroscience

    Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

    Gabriella R Sterne, Hideo Otsuna ... Kristin Scott
    A split-GAL4 collection provides precise genetic targeting of 138 neuronal cell types in the subesophageal zone of adult Drosophila melanogaster.
    1. Neuroscience

    Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

    Marco Leibinger, Charlotte Zeitler ... Dietmar Fischer
    Systemic treatment with di-methyl-amino-parthenolide facilitates CNS axon regeneration and functional recovery by reducing the induction of microtubule detyrosination by established regenerative therapies.

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