The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
Cori K Cahoon, Colette M Richter ... Diana E Libuda
Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.
Sarcoidosis, a granulomatous disease characterized by macrophage and T-cell activation, is found to be associated with increased HIF-1α transcriptional activity, and modulation of HIF-1α regulates inflammatory immune responses.
Sebastián Loyola, Tycho M Hoogland ... Chris I De Zeeuw
Experimental work and computational models reveal how the timing between the inhibitory and excitatory inputs modulates the function of the inferior olive nucleus, a key structure for motor learning and cognition.
Franck Ladam, William Stanney ... Charles G Sagerström
TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.
George A Spirou, Matthew Kersting ... Paul B Manis
Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.