1,169 results found
    1. Neuroscience

    Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs

    Ming Wu, Aljoscha Nern ... Gerald M Rubin
    Neurons called lobula columnar cells help fruit flies respond appropriately to specific visual cues, such as those signaling an approaching predator.
    1. Developmental Biology

    A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree

    Marta Losa, Victor Latorre ... Nicoletta Bobola
    The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
    1. Evolutionary Biology
    2. Neuroscience

    Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques

    Luqi Cheng, Yuanchao Zhang ... Tianzi Jiang
    Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Developmental Biology

    Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

    Xue Hao, Shimin Wang ... Lei Zhang
    The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

    Cori K Cahoon, Colette M Richter ... Diana E Libuda
    Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.
    1. Medicine
    2. Immunology and Inflammation

    HIF-1α regulates IL-1β and IL-17 in sarcoidosis

    Jaya Talreja, Harvinder Talwar ... Lobelia Samavati
    Sarcoidosis, a granulomatous disease characterized by macrophage and T-cell activation, is found to be associated with increased HIF-1α transcriptional activity, and modulation of HIF-1α regulates inflammatory immune responses.
    1. Neuroscience

    How inhibitory and excitatory inputs gate output of the inferior olive

    Sebastián Loyola, Tycho M Hoogland ... Chris I De Zeeuw
    Experimental work and computational models reveal how the timing between the inhibitory and excitatory inputs modulates the function of the inferior olive nucleus, a key structure for motor learning and cognition.
    1. Developmental Biology

    TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

    Franck Ladam, William Stanney ... Charles G Sagerström
    TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.
    1. Computational and Systems Biology
    2. Neuroscience

    High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

    George A Spirou, Matthew Kersting ... Paul B Manis
    Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.

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