Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.

Computational methods were used to develop accurate manual scorecards for early detection of participants at risk of type 2 diabetes based on the UK Biobank database.

To quantify serum or antibody activity against HIV-1, logistic regression of single-dilution neutralization outcomes can efficiently summarize neutralization potency and indicate which samples may lack sufficient statistical support, for high-throughput screening in large-scale vaccine trials.

In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.

A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.

Clinical prediction rules could help identify children at risk of slowed growth after an episode of diarrheal illness, and these rules may be generalizable to all children, regardless of diarrhea status.

The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.

Biomedical doctoral students and those from historically excluded groups exhibit higher rates of mental distress, which worsened in 2020 for some populations.

Variation in SARS-CoV-2 viral kinetics are partly explained by an individual's immune state and the infecting variant, but substantial interpersonal variation limits the reliability of isolation policies tailored to an individual's vaccination status.

Combined analyses of publicly available population-level variant data and detailed individual-level clinical data can be used to quantify the clinical impact of new SARS-CoV-2 variants in different settings.