2,321 results found
    1. Plant Biology

    Testing the Münch hypothesis of long distance phloem transport in plants

    Michael Knoblauch, Jan Knoblauch ... N Michele Holbrook
    Measurements of physiological and geometrical parameters of the sieve tube system in Ipomoea nil provide strong support for pressure driven mass flow.
    1. Plant Biology

    Long Distance Transport: Under pressure

    Ulrich Z Hammes
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    1. Genetics and Genomics
    2. Neuroscience

    Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

    Li Hou, Siyuan Guo ... Xianhui Wang
    CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.
    1. Neuroscience

    BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

    Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix ... Francisca C Bronfman
    BDNF axonal signaling regulates protein synthesis in neuronal cell bodies leading to dendritic arborization through dynein-dependent transport of signaling endosomes.
    1. Cell Biology

    RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

    Mark A McClintock, Carly I Dix ... Simon L Bullock
    Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
    1. Physics of Living Systems

    Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

    Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
    Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
    1. Structural Biology and Molecular Biophysics

    An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

    Zhao Wang, Guizhen Fan ... Dijun Du
    The tripartite drug efflux pump AcrA-AcrB-TolC, representative of a wide group of pumps from Gram-negative bacteria, enters a transport-competent state through long-distance conformational changes that switch the channel from a closed to an open state.
    1. Developmental Biology
    2. Cell Biology

    Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

    Ariel M Pani, Bob Goldstein
    Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

    Marina Diskowski, Ahmad Reza Mehdipour ... Inga Hänelt
    The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.

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