CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix ... Francisca C Bronfman
BDNF axonal signaling regulates protein synthesis in neuronal cell bodies leading to dendritic arborization through dynein-dependent transport of signaling endosomes.
Mark A McClintock, Carly I Dix ... Simon L Bullock
Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
The tripartite drug efflux pump AcrA-AcrB-TolC, representative of a wide group of pumps from Gram-negative bacteria, enters a transport-competent state through long-distance conformational changes that switch the channel from a closed to an open state.
Marina Diskowski, Ahmad Reza Mehdipour ... Inga Hänelt
The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.