14,107 results found
    1. Neuroscience

    Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons

    Yujin Kim, Ching-Lung Hsu ... Nelson Spruston
    At distal synapses onto hippocampal CA1 pyramidal neurons, synaptic plasticity is dependent on dendritically initiated sodium spikes, thus establishing a new role for voltage-gated sodium channels in the dendrites that may have important implications for how learning rules are implemented.
    1. Stem Cells and Regenerative Medicine

    In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye, David R Hill ... Jason R Spence
    Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.
    1. Epidemiology and Global Health

    Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

    Ricardo Cortez Cardoso Penha, Karl Smith-Byrne ... James D Mckay
    A novel Mendelian randomisation framework unravels one gene expression component, correlated with proliferation and genome stability-related features, associated with telomere length in lung adenocarcinoma tumours, which provides insights into how telomere length influences the genetic basis of lung cancer aetiology.
    1. Cancer Biology
    2. Cell Biology

    EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

    Ariel Pribluda, Anneleen Daemen ... Melissa R Junttila
    G9a regulates chromatin-bound b-catenin enabling cell-intrinsic control of WNT signaling-mediated cell fate decisions.
    1. Cancer Biology
    2. Cell Biology

    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Magda Spella, Ioannis Lilis ... Georgios T Stathopoulos
    Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
    1. Structural Biology and Molecular Biophysics

    Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

    Ho Yee Joyce Fung, Szu-Chin Fu, Yuh Min Chook
    Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.
    1. Neuroscience

    Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity

    Tianyu Tang, Timothy A Blenkinsop, Eric J Lang
    The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.
    1. Evolutionary Biology

    The genetic architecture of gene expression levels in wild baboons

    Jenny Tung, Xiang Zhou ... Yoav Gilad
    RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
    1. Developmental Biology
    2. Evolutionary Biology

    Lung evolution in vertebrates and the water-to-land transition

    Camila Cupello, Tatsuya Hirasawa ... Paulo M Brito
    The primitive state of vertebrate lungs is unpaired, evolving to be truly paired in the lineage towards the tetrapods, increasing the pulmonary efficiency during the water-to-land transition.
    1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott
    A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.

Refine your results by:

Type
Research categories