1,484 results found
    1. Immunology and Inflammation

    Defining murine monocyte differentiation into colonic and ileal macrophages

    Mor Gross-Vered, Sébastien Trzebanski ... Steffen Jung
    Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.
    1. Cell Biology
    2. Immunology and Inflammation

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias, Halil Ibrahim Aksoylar ... Tiffany Horng
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    1. Immunology and Inflammation

    Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

    Olga Barreiro, Danay Cibrian ... Francisco Sánchez Madrid
    A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.
    1. Immunology and Inflammation

    MicroRNAs of the miR-17~92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

    Xiang Zhang, Jianguo Liu ... Xiaoyu Hu
    miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
    1. Cell Biology

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius, Sam Virtue ... Antonio Vidal-Puig
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of polarized macrophage subsets in zebrafish

    Mai Nguyen-Chi, Béryl Laplace-Builhe ... Farida Djouad
    The discovery of evolutionarily conserved macrophage subsets in zebrafish paves the way for a comprehensive study of macrophage behaviour and function.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

    Alexandre Giraud-Gatineau, Juan Manuel Coya ... Ludovic Tailleux
    The anti-tuberculosis drug bedaquiline reprograms human macrophages into potent bactericidal phagocytes, which are able to control bacterial infection.
    1. Cancer Biology
    2. Immunology and Inflammation

    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

    Andrea Walens, Ashley V DiMarco ... James V Alvarez
    CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
    1. Microbiology and Infectious Disease

    Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

    Jade Leiba, Tamara Sipka ... Mai E Nguyen-Chi
    Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.
    1. Cell Biology
    2. Immunology and Inflammation

    Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

    Andrea Santeford, Aaron Y Lee ... Rajendra S Apte
    MicroRNA-146b regulates aging, activation, and mitochodrial function in thioglycollate-elicited peritoneal macrophages.

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