16,334 results found
    1. Cell Biology
    2. Genetics and Genomics

    LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

    Jae Yeon Hwang, Pengxin Chai ... Jean-Ju Chung
    LRRC23 is a radial spoke 3 head component essential for normal sperm motility and fertility in mammals.
    1. Developmental Biology
    2. Evolutionary Biology

    Molecular insights into the origin of the Hox-TALE patterning system

    Bruno Hudry, Morgane Thomas-Chollier ... Samir Merabet
    Interactions between Hox and TALE genes, which generate bilaterally symmetrical body plans, originated in early multicellular animals.
    1. Genetics and Genomics
    2. Neuroscience

    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

    Caryn R Hale, Kirsty Sawicka ... Robert B Darnell
    Combining compartment- and cell-type specific transcriptomic approaches reveals FMRP regulation of synaptic regulators in the dendrites and chromatin regulators in the cell bodies of CA1 neurons.
    1. Developmental Biology
    2. Genetics and Genomics

    Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves

    Melanie MY Chan, Omid Sadeghi-Alavijeh ... Daniel P Gale
    A genome-wide association study using whole-genome sequencing data identifies the first known susceptibility genes for posterior urethral valves, the most common cause of kidney failure in boys, implicating the transcription factor TBX5 and planar cell polarity gene PTK7.
    1. Neuroscience

    A time-stamp mechanism may provide temporal information necessary for egocentric to allocentric spatial transformations

    Avner Wallach, Erik Harvey-Girard ... Len Maler
    A novel neural mechanism for precise, unbiased estimation of time intervals in the thalamus of electric fish is likely used for computing distance between object encounters.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

    Michael J Rale, Brianna Romer ... Sabine Petry
    An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
    1. Cell Biology
    2. Developmental Biology

    ZMYND10 functions in a chaperone relay during axonemal dynein assembly

    Girish R Mali, Patricia L Yeyati ... Pleasantine Mill
    Chaperoning defects in axonemal dynein subunits trigger proteostatic clearance of dynein motors opening up the possibility of trialling proteostasis modulators to treat the motile ciliopathy primary ciliary dyskinesia (PCD).
    1. Neuroscience

    Acoustic duetting in Drosophila virilis relies on the integration of auditory and tactile signals

    Kelly M LaRue, Jan Clemens ... Mala Murthy
    Quantitative behavioral assays and modeling show that acoustic duetting in Drosophila during courtship relies on the detection of precisely timed cues via multiple sensory channels.
    1. Cell Biology
    2. Genetics and Genomics

    A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

    Maulik R Patel, Ganesh K Miriyala ... Harmit S Malik
    A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

    Dhruva Katrekar, Yichen Xiang ... Prashant Mali
    A deep mutational scan of the ADAR2 deaminase domain creates a map for designing tailored ADAR2 variants, and splitting the deaminase between residues 468 and 469 enables highly transcript-specific RNA editing.

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