Coordination between crossover designation and synaptonemal complex disassembly is executed via a conserved MAP kinase pathway and is critical for accurate chromosome segregation during meiosis.

Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.

The first three-dimensional structure of the PI3KC3 complex I, which is involved in autophagy, provides a framework for understanding the allosteric regulation of lipid kinase activity.

Two seemingly distinct cellular stress response pathways that contribute to neurodegeneration after axonal insults are now revealed to be under the control of a single master regulator of the neuronal injury response, the kinase DLK.

Cryo-electron microscopy structures of full-length P5CS, the proline synthesis enzyme, reveal that filamentation is crucial for the coordinated catalytic reactions between the glutamate kinase and γ-glutamyl phosphate reductase domains.

Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.

A role for FGF-mediated Map Kinase signaling in the retention of pluripotency underlying genesis of Neural Crest is revealed, along with a striking switch in the signaling cascades activated by FGF signaling as cells commence lineage restriction.

An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.

Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.