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Neuroscience
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration
Xinde Zheng, Leah Boyer ... Tony Hunter
Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Structural basis of proton translocation and force generation in mitochondrial ATP synthase
Niklas Klusch, Bonnie J Murphy ... Werner Kühlbrandt
Cryo-EM reveals atomic details of two membrane half-channels for translocation of protons that drive rotary catalysis in ATP synthase.
Developmental Biology
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
Xinde Zheng, Leah Boyer ... Tony Hunter
The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
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