3 results found
    1. Neuroscience

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng, Leah Boyer ... Tony Hunter
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of proton translocation and force generation in mitochondrial ATP synthase

    Niklas Klusch, Bonnie J Murphy ... Werner Kühlbrandt
    Cryo-EM reveals atomic details of two membrane half-channels for translocation of protons that drive rotary catalysis in ATP synthase.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng, Leah Boyer ... Tony Hunter
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.

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