14,144 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

    Cassandra L Stowe, Thomas A Burley ... Martin A Pule
    Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin, Erin Nicole Sanders ... Lucy Erin O'Brien
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Neuroscience

    Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T

    Kevin R Sitek, Omer Faruk Gulban ... Federico De Martino
    MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

    Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
    Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

    Gregory M Martin, Craig Yoshioka ... Show-Ling Shyng
    Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (KATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.
    1. Neuroscience

    Humans actively sample evidence to support prior beliefs

    Paula Kaanders, Pradyumna Sepulveda ... Benedetto De Martino
    In a perceptual choice task, human participants have a preference for sampling more information from a previously chosen alternative, indicating the presence of 'confirmation bias' in perceptual decision-making.
    1. Structural Biology and Molecular Biophysics

    Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

    Marina A Kasimova, Debanjan Tewari ... Baron Chanda
    The gating polarity of a voltage-gated ion channel is primarily determined by turn propensity of residues at a critical position in the middle of the S4 voltage-sensing helix.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

    Austin H Patton, Emilie J Richards ... Christopher H Martin
    Hybridization not only generates genetic diversity, but this diversity can alter the shape of the fitness landscape, changing which genotypic combinations are favored by natural selection and which accessible genotypic paths lead to novel fitness peaks.
    1. Neuroscience

    The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

    Anders Martin Fjell, Hakon Grydeland ... Kristine Beate Walhovd
    Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and age-invariant relationships to cognition.
    1. Chromosomes and Gene Expression

    Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

    Joyce Rigal, Ane Martin Anduaga ... Michael T Marr
    A genetic approach indicates that increased active somatic transposon activity can decrease life span and affect some but not all hallmarks of aging.

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