1,419 results found
    1. Neuroscience
    2. Physics of Living Systems

    Rapid mechanical stimulation of inner-ear hair cells by photonic pressure

    Sanjeewa Abeytunge, Francesco Gianoli ... Andrei S Kozlov
    A new method is described to apply rapid and uniform mechanical forces to vestibular and cochlear hair cells.
    1. Cell Biology
    2. Immunology and Inflammation

    A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

    Jia C Wang, Yang-In Yim ... John A Hammer
    B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.
    1. Stem Cells and Regenerative Medicine

    Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

    Han Xiao, Tao Zhang ... Hongbin Lu
    The proper mechanical stimulus could promote the migration of Prrx1+ cells to the injury site to enhance enthesis injury repair.
    1. Cell Biology

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li, Li Han ... Jinhu Xiong
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
    1. Physics of Living Systems
    2. Neuroscience

    Direct mechanical stimulation of tip links in hair cells through DNA tethers

    Aakash Basu, Samuel Lagier ... AJ Hudspeth
    The ability of hair cells to produce an electrical signal in response to a mechanical stimulus stems from tension in the elastic tip links within the bundles.
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    1. Computational and Systems Biology
    2. Developmental Biology

    Why plants make puzzle cells, and how their shape emerges

    Aleksandra Sapala, Adam Runions ... Richard S Smith
    Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.
    1. Physics of Living Systems

    Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing

    Alessandro Sanzeni, Samata Katta ... Massimo Vergassola
    Nonlinear elasticity of skin tissues and somatosensory neural responses are combined to predict and test C. elegans processing of touch stimuli and modifications due to changes in the body mechanics.
    1. Physics of Living Systems
    2. Developmental Biology

    Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

    Tae-Jin Kim, Chirlmin Joo ... Yingxiao Wang
    Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.
    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo, Stanisa Raspopovic ... Silvestro Micera
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
    1. Cell Biology
    2. Neuroscience

    Keratinocyte PIEZO1 modulates cutaneous mechanosensation

    Alexander R Mikesell, Olena Isaeva ... Cheryl L Stucky
    Epidermal PIEZO1 is a key keratinocyte mechanotransducer which mediates normal behavioral and sensory neuron responses to cutaneous mechanical stimulation.

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