209 results found
    1. Cell Biology
    2. Neuroscience

    Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

    A Catalina Vélez-Ortega, Mary J Freeman ... Gregory I Frolenkov
    The remarkable lifelong stability of mechanotransducing stereocilia of the inner ear hair cells depends on the activity of the transduction ion channels located at the tips of these mechanosensory projections.
    1. Neuroscience

    Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

    Timothy Erickson, Clive P Morgan ... Teresa Nicolson
    A zebrafish model for a particular form of human deafness (DFNB63) changes our view of this disease by revealing a defect in the localization of Transmembrane channel-like proteins that are essential for mechanotransduction in sensory cells.
    1. Neuroscience

    The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

    Christopher L Cunningham, Zizhen Wu ... Ulrich Müller
    Murine TOMT is essential for transport of mechanotransduction components to stereocilia in cochlear hair cells.
    1. Cell Biology

    Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

    Pratibha Narayanan, Meike Hütte ... Manuela Schmidt
    Local Mtmr2 activity and PI(3,5)P2 abundance dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons.
    1. Computational and Systems Biology

    Fibroblast mechanotransduction network predicts targets for mechano-adaptive infarct therapies

    Jesse D Rogers, William J Richardson
    Mechanotransduction signaling analysis suggests that mechanical tension can sensitize, desensitize, and reverse cell responses to biochemical agonists, as well as provide mechano-adaptive targets for regionally specific drug responses.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper, Démosthène Mitrossilis ... Emmanuel Farge
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Developmental Biology

    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

    Taifeng Zhou, Bo Gao ... Yingzi Yang
    Mechanosensitive channels Piezo1/2 are required for osteoblast differentiation from progenitors by sensing fluid sheer stress and matrix rigidity and regulating NFATc1, YAP1 and ß-catenin activities through Ca2+ stimulated phosphatase calcineurin.
    1. Cancer Biology
    2. Cell Biology

    DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

    Samantha VH Bayer, Whitney R Grither ... Gregory D Longmore
    The action of the collagen receptor DDR2 in CAFs regulates Rap1-Talin1 mediated Integrin mechanotransduction in breast tumors to impact tumor stiffness and metastases.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

    M Rocio Servin-Vences, Mirko Moroni ... Kate Poole
    The application of different types of mechanical stimuli to chondrocytes, either by stretching the membrane or deflecting cell-substrate contacts, reveals that there are distinct but overlapping mechanoelectrical transduction pathways in these cells.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros, Cristina Fenollar-Ferrer, Kenton Jon Swartz
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.

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