1,057 results found
    1. Neuroscience

    Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

    Tim James Viney, Minas Salib ... Peter Somogyi
    GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella, Valentina Mastrorilli ... Marilena Griguoli
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan, Thomas Meyer ... Marlene Bartos
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

    Nikolaos Vardalakis, Amélie Aussel ... Fabien B Wagner
    Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.
    1. Neuroscience

    Synchronized excitability in a network enables generation of internal neuronal sequences

    Yingxue Wang, Zachary Roth, Eva Pastalkova
    Hippocampal sharp-wave sequences, which are considered the key phenomenon underlying consolidation of episodic memory, are preserved even after an animal’s memory is impaired.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of sequentially generated septal neuron fates

    Miguel Turrero García, Sarah K Stegmann ... Corey C Harwell
    A combination of single-cell RNA sequencing of the developing septum and genetic fate mapping is used to analyze the origin of septal neurons.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

    Kanika Khanna, Javier Lopez-Garrido ... Elizabeth Villa
    During sporulation, FtsAZ filaments mediating cell division in Bacillus subtilis are positioned asymmetrically around the septum only on the mother cell side, making the septum thinner than during vegetative growth.
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski, Clara S Tang ... Y Audrey Hay
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Neuroscience

    No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation

    Lilya Andrianova, Steliana Yanakieva ... Michael T Craig
    A combination of anterograde and retrograde anatomical-tracing methods failed to provide evidence of a recently described projection from the anterior cingulate area to the hippocampus.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic, Javier López-Garrido ... Robert G Endres
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.

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