6,281 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

    Amanda M Hughes, Eleanor Sanderson ... Neil M Davies
    It is unclear how much a child's BMI at age 8 affects their depressive and ADHD symptoms after family-level factors are accounted for, but a substantial impact on anxiety symptoms is unlikely.
    1. Medicine

    Meta-research: justifying career disruption in funding applications, a survey of Australian researchers

    Adrian Barnett, Katie Page ... Susanna Cramb
    A survey of health and medical researchers revealed important diffrences in how career disruption is treated in funding decisions, with differences in what applicants with disruption are willing to divulge and the adjustments made by reviewers.
    1. Epidemiology and Global Health

    Environment- and epigenome-wide association study of obesity in ‘Children of 1997’ birth cohort

    Jie Zhao, Bohan Fan ... C Mary Schooling
    The comprehensive assessment on environmental factors and epigenetics with obesity provides novel insights into potentially modifiable factors related to obesity at the outset and the end of puberty, with close relevance to health policy and public health.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

    Bronner P Gonçalves, Matthew Hall ... ISARIC Clinical Characterisation Group
    Combined analyses of publicly available population-level variant data and detailed individual-level clinical data can be used to quantify the clinical impact of new SARS-CoV-2 variants in different settings.
    1. Neuroscience

    The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

    Christoph Wiest, Flavie Torrecillos ... Huiling Tan
    The slope of the power spectrum of subthalamic local field potentials tracks pathological states in Parkinson’s disease and likely complements beta activity as a feedback marker for adaptive deep brain stimulation.
    1. Medicine

    Tracing the path of 37,050 studies into practice across 18 specialties of the 2.4 million published between 2011 and 2020

    Moustafa Abdalla, Salwa Abdalla, Mohamed Abdalla
    Comprehensive decade-long analysis of point-of-care resources reveals insights into how clinical research makes its way into practice across different medical specialties and through time to enable us to identify potential translational bottlenecks in the pathway from research to practice.
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
    SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
    1. Cancer Biology
    2. Medicine

    Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period

    Hiba Dagher, Anne-Marie Chaftari ... Issam I Raad
    Long COVID occurred in the majority of cancer patients diagnosed with acute COVID-19 with a preponderance of symptoms (such as fatigue, sleep disturbances, and gastrointestinal symptoms) over a long time period.
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    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study

    Peh Joo Ho, Iain BeeHuat Tan ... Jingmei Li
    Site-specific polygenic risk scores can stratify the risk of developing breast, prostate, and colorectal cancers in this East Asian population.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Identifying metabolic features of colorectal cancer liability using Mendelian randomization

    Caroline Bull, Emma Hazelwood ... Emma E Vincent
    Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.

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