A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
Ca2+-free synaptotagmin-1 binds to neuronal SNARE complexes anchored on nanodiscs, and Ca2+ releases this interaction to induce tight, specific binding to PIP2-containing membranes.
Methylomic and trancriptomic analyses demonstrate the regulation of the toll-like receptor 4 inflammatory gene expression, an essential actor of the fetal membrane weakening at the end of pregnancy.
Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
Unbiased molecular dynamics simulations reveal the insertion mechanism of the lipidated tail of the matrix domain of HIV-1 Gag into realistic membrane models and show its effect on lipid sorting.
Luisa CS Antunes, Daniel Poppleton ... Simonetta Gribaldo
Phylogenomics provides support for the Gram-positive type of bacterial cell envelope being a derived character that arose independently multiple times through loss of an ancestral outer membrane.
The asymmetric combination of saturated and polyunsaturated acyl chains in phospholipids as typically observed in synapses makes membranes prone to deformation and fission without compromising their impermeability.
Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.
Alam García-Heredia, Takehiro Kado ... M Sloan Siegrist
Mycobacteria employ plasma membrane compartments to organize their cell wall synthesis, and the finalized cell wall compartmentalizes the plasma membrane to promote an environment conducive to its own synthesis.