8,916 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti, Simone Prinz ... John AG Briggs
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

    Rashmi Voleti, Klaudia Jaczynska, Josep Rizo
    Ca2+-free synaptotagmin-1 binds to neuronal SNARE complexes anchored on nanodiscs, and Ca2+ releases this interaction to induce tight, specific binding to PIP2-containing membranes.
    1. Cell Biology
    2. Genetics and Genomics

    Physiological TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case

    Corinne Belville, Flora Ponelle-Chachuat ... Loïc Blanchon
    Methylomic and trancriptomic analyses demonstrate the regulation of the toll-like receptor 4 inflammatory gene expression, an essential actor of the fetal membrane weakening at the end of pregnancy.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Structural Biology and Molecular Biophysics

    Binding mechanism of the matrix domain of HIV-1 gag on lipid membranes

    Viviana Monje-Galvan, Gregory A Voth
    Unbiased molecular dynamics simulations reveal the insertion mechanism of the lipidated tail of the matrix domain of HIV-1 Gag into realistic membrane models and show its effect on lipid sorting.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

    Luisa CS Antunes, Daniel Poppleton ... Simonetta Gribaldo
    Phylogenomics provides support for the Gram-positive type of bacterial cell envelope being a derived character that arose independently multiple times through loss of an ancestral outer membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

    Marco M Manni, Marion L Tiberti ... Bruno Antonny
    The asymmetric combination of saturated and polyunsaturated acyl chains in phospholipids as typically observed in synapses makes membranes prone to deformation and fission without compromising their impermeability.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang, Yan Zhang ... Fei Sun
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Cell Biology
    2. Immunology and Inflammation

    SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

    Manuela Ecker, Richard Schregle ... Jeremie Rossy
    Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.
    1. Biochemistry and Chemical Biology

    Membrane-partitioned cell wall synthesis in mycobacteria

    Alam García-Heredia, Takehiro Kado ... M Sloan Siegrist
    Mycobacteria employ plasma membrane compartments to organize their cell wall synthesis, and the finalized cell wall compartmentalizes the plasma membrane to promote an environment conducive to its own synthesis.

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