4,421 results found
    1. Neuroscience

    Unique membrane properties and enhanced signal processing in human neocortical neurons

    Guy Eyal, Matthijs B Verhoog ... Idan Segev
    Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
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    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.
    1. Neuroscience
    2. Physics of Living Systems

    Mathematical relationships between spinal motoneuron properties

    Arnault H Caillet, Andrew TM Phillips ... Luca Modenese
    Validated mathematical relationships between motoneuron morphometric and electrophysiological properties are provided as a tool for neuroscientists and modellers to generate hypotheses for experimental studies investigating currently unreported relationships and build virtual motoneuron profiles with consistent properties for modelling purposes.
    1. Structural Biology and Molecular Biophysics

    Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

    Rahul Chadda, Nathan Bernhardt ... Janice L Robertson
    Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
    1. Cell Biology
    2. Neuroscience

    Unconventional secretory processing diversifies neuronal ion channel properties

    Cyril Hanus, Helene Geptin ... Erin M Schuman
    Imaging, quantitative immunoblotting and mass spectrometry reveal that hundreds of surface-expressed neuronal membrane proteins exhibit atypical glycosylation profiles, resulting in changes in protein half-life and synaptic responses.
    1. Neuroscience

    Thalamocortical synapses in the cat visual system in vivo are weak and unreliable

    Madineh Sedigh-Sarvestani, Larry A Palmer, Diego Contreras
    A characterization of LGN-V1 synaptic transmission properties demonstrates thalamocortical synapses in vivo are weak and unreliable, but biologically constrained models show they efficiently drive cortex.
    1. Structural Biology and Molecular Biophysics

    Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

    Kanchan Gupta, Maryam Zamanian ... Kenton J Swartz
    The tarantula toxins psalmotoxin and guangxitoxin have a similar concave surface for interacting with α-helices in voltage-gated and acid-sensing ion channels.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular basis of the PIP2-dependent regulation of CaV2.2 channel and its modulation by CaV β subunits

    Cheon-Gyu Park, Wookyung Yu, Byung-Chang Suh
    The anchoring properties of CaV β2 subunits to the plasma membrane determine the biophysical states of CaV2.2 channels by regulating PIP2 coupling to the nonspecific phospholipid-binding site in the I–II loop.
    1. Structural Biology and Molecular Biophysics

    Effect of helical kink in antimicrobial peptides on membrane pore formation

    Alzbeta Tuerkova, Ivo Kabelka ... Robert Vácha
    Proline/glycine kink in the helical peptides affects the peptide ability to form membrane pores by stabilising toroidal pore structures but disrupting barrel-stave pore structures.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang, Baochang Fan ... J Paul Taylor
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.

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