1,805 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Nanoscale protein architecture of the kidney glomerular basement membrane

    Hani Suleiman, Lei Zhang ... Adish Dani
    High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The architecture of EMC reveals a path for membrane protein insertion

    John P O'Donnell, Ben P Phillips ... Ramanujan S Hegde
    Structural and biochemical analysis of an abundant and conserved protein complex called EMC shows how it is likely to insert nascent membrane proteins into the endoplasmic reticulum membrane.
    1. Cell Biology

    Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function

    Logesvaran Krshnan, Wingyan Skyla Siu ... Pedro Carvalho
    Biochemical and genetic approaches revealed a posttranslational mechanism controlling the abundance of SUN2, a critical nuclear envelope protein.
    1. Cell Biology

    Nanoscale architecture of the Schizosaccharomyces pombe contractile ring

    Nathan A McDonald, Abigail L Lind ... Kathleen L Gould
    Super-resolution microscopy reveals the nanoscale molecular architecture of 29 protein components of a eukaryotic contractile ring relative to the membrane.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Determinants shaping the nanoscale architecture of the mouse rod outer segment

    Matthias Pöge, Julia Mahamid ... Wolfgang Baumeister
    Cryo-electron tomography of close-to-native rod outer segments resolves connectors between disks and a scaffold at the disk rim enforcing the high membrane curvature of the unique long-range organization in these rhodopsin-rich light-sensitive subcellular organelles.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualizing the functional architecture of the endocytic machinery

    Andrea Picco, Markus Mund ... Marko Kaksonen
    A combination of light and electron microscopy data provide new insights into the dynamic architecture and the function of the endocytic protein machinery in relation to membrane shape changes in vivo.
    1. Cell Biology
    2. Developmental Biology

    The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

    Sophie M Morgani, Jie Su ... Anna-Katerina Hadjantonakis
    Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn, Zehao Li ... Changjiang You
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.

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