6,739 results found
    1. Structural Biology and Molecular Biophysics

    Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake

    Inokentijs Josts, Katharina Veith, Henning Tidow
    The crystal structure of a ternary complex of a TonB-dependent transporter containing a signalling domain, bound to siderophore as well as TonB, provides mechanistic insights into siderophore uptake and signalling.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A structural model of the active ribosome-bound membrane protein insertase YidC

    Stephan Wickles, Abhishek Singharoy ... Roland Beckmann
    A cryo-EM structure combined with bioinformatics provide a structural view on a conserved co-translational membrane protein biogenesis pathway.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

    Lan Wang, Hannah Toutkoushian ... Peter Walter
    A mitochondrial membrane-bound protein ATAD1 uses conserved structural elements to remove mislocalized membrane proteins from the outer mitochondrial membrane, achieving proper cell organization.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

    Christophe Caillat, Delphine Guilligay ... Winfried Weissenhorn
    The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa

    Florian Bleffert, Joachim Granzin ... Filip Kovacic
    Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

    Diana C Rodriguez Camargo, Kyle J Korshavn ... Ayyalusamy Ramamoorthy
    The ability of lipid nanodiscs to trap different types of amyloid intermediates, as successfully demonstrated in this study for human-IAPP, could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

    Katharina van Pee, Alexander Neuhaus ... Özkan Yildiz
    The near-atomic cryoEM pore complex structure of pneumolysin, the main virulence factor of Streptococcus pneumoniae, shows how the individual domains rearrange during the pore formation.
    1. Cell Biology

    Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

    Lisa M Strong, Chunmei Chang ... James H Hurley
    The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

    Lakshmi E Miller-Vedam, Bastian Bräuning ... Jonathan S Weissman
    Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

    Chanhyung Bae, Claudio Anselmi ... Kenton J Swartz
    The structure of a bivalent double-knot tarantula toxin bound to the outer pore of the capsaicin receptor reveals a novel mode of toxin-channel recognition that has important implications for thermosensation.

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