3,441 results found
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew, Antonis Tatarakis ... Danesh Moazed
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.
    1. Physics of Living Systems

    Cells use molecular working memory to navigate in changing chemoattractant fields

    Akhilesh Nandan, Abhishek Das ... Aneta Koseska
    Combined experimental and theoretical analysis identifies a molecular mechanism akin to working memory that enables single cells to perform complex navigation tasks in changing growth factor fields, beyond simple stimulus-response associations.
    1. Neuroscience

    Cortico-hippocampal network connections support the multidimensional quality of episodic memory

    Rose A Cooper, Maureen Ritchey
    Enhanced hippocampal-cortical network communication during memory retrieval flexibly tracks the quality and content of memories for complex past events.
    1. Neuroscience

    Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation

    Josué Haubrich, Matteo Bernabo, Karim Nader
    The overactivation of noradrenergic inputs to the amygdala during severe fear learning increases memory stability at the expense of lability, rendering the trace resistant to memory destabilization and reconsolidation.
    1. Neuroscience

    The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature

    Weizhen Xie, Marcus Cappiello ... Weiwei Zhang
    High-resolution fMRI data reveal an often-neglected contribution of the medial temporal lobe circuitry to item-specific representation in visual working memory, suggesting the mechanism traditionally deemed dedicated to long-term memory can be exploited to support the quality of human working memory.
    1. Neuroscience

    Valence biases in reinforcement learning shift across adolescence and modulate subsequent memory

    Gail M Rosenbaum, Hannah L Grassie, Catherine A Hartley
    Relative to children and adults, adolescents placed greater weight on negative prediction errors during learning and these age-varying learning idiosyncrasies biased subsequent memory for information associated with valenced outcomes.
    1. Neuroscience

    Long-term implicit memory for sequential auditory patterns in humans

    Roberta Bianco, Peter MC Harrison ... Maria Chait
    Human listeners rapidly form robust, long lasting (up to 7 weeks) memories of rarely encountered, featureless sound sequences presented among many similar stimuli.
    1. Neuroscience

    The causal role of auditory cortex in auditory working memory

    Liping Yu, Jiawei Hu ... Jinghong Xu
    Auditory cortex is essential for information encoding and maintenance in auditory working memory, especially during the early delay period.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys

    Jon C Emery, Peter J Dodd ... Rein MGJ Houben
    Data analysis and mathematical modelling suggest that subclinical tuberculosis contributes substantially to transmission and needs to be diagnosed and treated for effective progress towards tuberculosis elimination.
    1. Immunology and Inflammation

    Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

    Isaac J Jensen, Xiang Li ... Vladimir P Badovinac
    Sepsis leads to lasting changes in the composition of the pre-existing memory CD8 T cell compartment leading to altered localization, changes in their transcriptional landscape and chromatin accessibility, differential function, and reduced capacity to control infection.

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