2,319 results found
    1. Immunology and Inflammation

    Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

    Isaac J Jensen, Xiang Li ... Vladimir P Badovinac
    Sepsis leads to lasting changes in the composition of the pre-existing memory CD8 T cell compartment leading to altered localization, changes in their transcriptional landscape and chromatin accessibility, differential function, and reduced capacity to control infection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

    George Elias, Pieter Meysman ... Benson Ogunjimi
    High-throughput sequencing of the memory T cell receptor repertoire and machine learning can predict robust antibody and CD4 T cell response to de novo hepatitis B vaccine.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina, Ekaterina A Komech ... Mikhail V Pogorelyy
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
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    1. Immunology and Inflammation

    Autophagy is a critical regulator of memory CD8+ T cell formation

    Daniel J Puleston, Hanlin Zhang ... Anna Katharina Simon
    Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

    Graeme Gossel, Thea Hogan ... Andrew J Yates
    The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.
    1. Immunology and Inflammation

    T cell-intrinsic role of IL-6 signaling in primary and memory responses

    Simone A Nish, Dominik Schenten ... Ruslan Medzhitov
    IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.
    1. Immunology and Inflammation

    Protective function and durability of mouse lymph node-resident memory CD8+ T cells

    Scott M Anthony, Natalija Van Braeckel-Budimir ... John T Harty
    Repeated antigen encounters alter the transcriptional state and function of lymph node-resident memory CD8+ T cells to mediate improved immunity against viral infection.
    1. Immunology and Inflammation

    The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation

    Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
    A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
    1. Immunology and Inflammation

    T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance

    Xin Gao, Kaiming Luo ... Di Yu
    By comparing different subsets in mouse inducible Tfh (iTfh) cells and human circulating Tfh (cTfh) cells after vaccination, Tfh17 cells were found to be better than Tfh1 or Tfh2 cells in maintenance and support immunological memory of humoral immunity.
    1. Immunology and Inflammation

    Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

    Thea Hogan, Maria Nowicka ... Benedict Seddon
    Comparing mice in clean and dirty environments reveals that environment drives initial establishment and size of T cell memory compartments, but not their maintenance in adults.

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