434 results found
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes, Fei Zhou ... Ralph Bock
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A general strategy to construct small molecule biosensors in eukaryotes

    Justin Feng, Benjamin W Jester ... David Baker
    A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast, mammalian cells and plants.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Light-inducible protein degradation in E. coli with the LOVdeg tag

    Nathan Tague, Cristian Coriano-Ortiz ... Mary J Dunlop
    The LOVdeg tag is a versatile tool for bacterial optogenetics, offering modular, blue light-inducible protein degradation for a range of synthetic biology and metabolic engineering applications.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Recreating the synthesis of starch granules in yeast

    Barbara Pfister, Antoni Sánchez-Ferrer ... Samuel C Zeeman
    Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

    Amanda K Garcia, Derek F Harris ... Betül Kaçar
    Life is constrained in its sampling of protein sequence space to catalyze one of the most energetically challenging biochemical reactions.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Science Forum: A low-cost, open-source evolutionary bioreactor and its educational use

    Vishhvaan Gopalakrishnan, Dena Crozier ... Jacob G Scott
    The EVolutionary biorEactor (EVE) can be built for less than $200, and can be used to evaluate microbial population dynamics in the lab and to teach evolution in high schools.
    1. Computational and Systems Biology
    2. Plant Biology

    Evolution of C4 photosynthesis predicted by constraint-based modelling

    Mary-Ann Blätke, Andrea Bräutigam
    Constraint-based modelling predicts C4 photosynthesis evolves under resource limitation from an ancestral ground state of C3 photosynthesis and attributes divergent metabolic routes in extant C4 subtypes to light.
    1. Neuroscience

    Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

    Frederic A Roemschied, Monika JB Eberhard ... Susanne Schreiber
    The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.
    1. Computational and Systems Biology

    Resource allocation accounts for the large variability of rate-yield phenotypes across bacterial strains

    Valentina Baldazzi, Delphine Ropers ... Hidde de Jong
    A coarse-grained model of microbial growth coupling fluxes of carbon and energy shows that resource allocation is a major explanatory factor of the observed variability of growth rates and growth yields across different bacterial strains.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolic interactions between dynamic bacterial subpopulations

    Adam Z Rosenthal, Yutao Qi ... Michael B Elowitz
    Metabolic division of labor in B. subtilis controls the extracellular environment.

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