323 results found
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian, Zhaofa Wu ... Yulong Li
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen, Deyang Xu ... Barbara Ann Halkier
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Neuroscience

    The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

    Yongchao Han, Liangyao Xiong ... Tao Wang
    BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Microbiology and Infectious Disease

    The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

    Hui Dong, Jiong Yang ... Shaojun Long
    Combined cutting-edge technologies discovered a pair of carboxylate transporters that appears evolutionarily different among novel transporters and that is essential for parasite physiology.
    1. Neuroscience

    The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Drew Stenesen, Andrew T Moehlman, Helmut Krämer
    Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Genetics and Genomics

    Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

    Courtney J Smith, Nasa Sinnott-Armstrong ... Jonathan K Pritchard
    Genetic variants acting between biologically related metabolite pairs often reflect biology local to the traits and have effect directions contrasting those of upstream or downstream variants, which can result in striking, biologically interpretable heterogeneity in genetic correlation across the genome.
    1. Neuroscience

    Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

    Fu Li, Gregory Artiushin, Amita Sehgal
    Metabolites, such as acylcarnitines, accumulate in Drosophila heads when endocytosis is blocked and reflects an increased need for sleep.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Molecular mechanisms of microbiome modulation by the eukaryotic secondary metabolite azelaic acid

    Ahmed A Shibl, Michael A Ochsenkühn ... Shady A Amin
    Characterization of the molecular mechanisms that enable azelaic acid, a secondary metabolite produced by photosynthetic organisms, to promote or inhibit different bacterial populations.
    1. Structural Biology and Molecular Biophysics

    Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates

    Ali A Kermani, Olive E Burata ... Randy B Stockbridge
    In the bacterial small multidrug transporter EmrE, sidechain rearrangements in the binding site accommodate structurally diverse substrates without major rearrangements of the protein backbone.
    1. Medicine

    Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

    Yifan Tu, Lu Wang ... Ming Hu
    A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.

Refine your results by:

Type
Research categories