51 results found
    1. Cell Biology
    2. Developmental Biology

    Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

    Jarrett Smith, Deepika Calidas ... Geraldine Seydoux
    A competition for RNA drives the localized assembly of RNA granules in the C. elegans embryo.
    1. Cell Biology
    2. Developmental Biology

    Germ Granules: All about the RNA after all

    Tatjana Trcek, Ruth Lehmann
    RNA molecules cause the proteins involved in the formation of germ granules to coalesce into liquid droplets.
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    1. Chromosomes and Gene Expression

    X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

    Qiming Yang, Te-Wen Lo ... Barbara J Meyer
    Regulatory hierarchies controlling sex determination and X-chromosome dosage compensation between closely-related nematode species are conserved, but X-chromosome target specificity for the condensin dosage compensation complex has diverged, thereby contributing to reproductive isolation.
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele, Rob Jelier, Pierre Gönczy
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
    1. Cell Biology
    2. Developmental Biology

    Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

    Mor Levi-Ferber, Rewayd Shalash ... Sivan Henis-Korenblit
    Neuronal circuits can be disrupted by ire-1-dependent mRNA decay to affect germline tumor cell identity by regulating cross-tissue communication in Caenorhabditis elegans.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu, Stephanie E Hallows ... Bret J Pearson
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

    Hugo G Castelán-Sánchez, Luis Delaye ... Marina Escalera Zamudio
    An in-depth exploratory analysis of the evolutionary and epidemiological dynamics of SARS-CoV-2 in Mexico during the first year of the epidemic provides an overview of different virus dynamics between the developing and developed world (represented by the USA and Mexico).
    1. Stem Cells and Regenerative Medicine

    Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

    Lisa Zipper, Denise Jassmann ... Tobias Reiff
    A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
    1. Developmental Biology

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

    Tobias Reiff, Jake Jacobson ... Irene Miguel-Aliaga
    A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.
    1. Genetics and Genomics

    Wild worm embryogenesis harbors ubiquitous polygenic modifier variation

    Annalise B Paaby, Amelia G White ... Matthew V Rockman
    Cryptic alleles affecting embryonic development are widespread in wild C. elegans populations.

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