Localized drug photoactivation provides light-mediated analgesia in behaving mice.

Functional analysis reveals a distinct mode of action of the allosteric modulators in the GABA_B receptor in a pocket that is formed only in the active state and identifies a region in the GABA_B2 subunit important for allosteric agonism.

Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.

Soluble amyloid-β precursor peptide has no functional effects at recombinant and native GABA_B receptors.

Being exposed to cannabinoids in the womb has different consequences for male and female rats. .

β-arrestins recruit Nedd4 ubiquitin E3 ligase to mGlu7 receptor and facilitate ubiquitination, endocytosis, ERK signaling, and stability of mGlu7 at presynaptic terminals.

SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.

Dimensionality reduction techniques reveal how the organization of neurotransmitter receptor and transporter co-expression in the human brain may bridge the gap between brain structure and function.

Adult male, but not female, rats showed altered neuronal function, inhibited synaptic plasticity and diminished social behavior following cannabinoid exposure during gestation in a model of cannabis use during pregnancy.