1,351 results found
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Structural Biology and Molecular Biophysics

    New tools for automated high-resolution cryo-EM structure determination in RELION-3

    Jasenko Zivanov, Takanori Nakane ... Sjors HW Scheres
    RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.
    1. Structural Biology and Molecular Biophysics

    Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A

    Christopher M Hoel, Lin Zhang, Stephen G Brohawn
    A cryo-EM structure of TMEM87A unexpectedly reveals it is structurally related to seven other proteins including Wntless, a chaperone for lipidated and secreted Wnt morphogens, suggesting GOLD-domain seven-transmembrane helix (GOST) proteins may all similarly traffic membrane-associated cargo.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong, Metta Riebesell ... Ralf J Sommer
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants

    Maria Maldonado, Fei Guo, James A Letts
    The structures of plant CIII2, CIV, and SC III2+IV challenge long-standing assumptions, generate new mechanistic hypotheses and allow for the generation of more selective agricultural inhibitors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a AAA+ unfoldase in the process of unfolding substrate

    Zev A Ripstein, Rui Huang ... John L Rubinstein
    The structure of a substrate-engaged AAA+ unfoldase suggests a model for processive unfolding that is supported by biochemical data.
    1. Structural Biology and Molecular Biophysics

    Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

    Stefan T Huber, Edin Sarajlic ... Arjen J Jakobi
    A novel strategy for reproducible cryo-EM sample preparation with minimal sample volumes.
    1. Plant Biology

    Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions

    Manuela Kramer, Melvin Rodriguez-Heredia ... Guy Thomas Hanke
    The regulatory switch from protection to assimilation, which plants use to exploit natural, fluctuating light, involves movement of the enzyme ferredoxin:NADP(H) oxidoreductase between chloroplast membrane complexes.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira, Nicholas MI Taylor ... Henning Stahlberg
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Structural Biology and Molecular Biophysics

    cisTEM, user-friendly software for single-particle image processing

    Timothy Grant, Alexis Rohou, Nikolaus Grigorieff
    cisTEM enables fast processing of single-particle cryo-EM data on CPU-based workstations and is easily accessible to new users.

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