951 results found
    1. Cell Biology

    A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation

    Binyam Mogessie, Daniel Roth ... Anne Straube
    oMAP4 is a microtubule crosslinker that restricts motor driven microtubule motility and cooperates with microtubule motors in the establishment of paraxial microtubule arrangements in differentiating muscle cells.
    1. Cell Biology
    2. Genetics and Genomics

    Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

    Jana Muroňová, Zine Eddine Kherraf ... Christophe Arnoult
    CCDC146 is a structural component of the flagellum in sperm, located in the doublet microtubules of the axoneme, whose absence leads to multiple morphological anomalies of the flagellum.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Autoregulatory control of microtubule binding in doublecortin-like kinase 1

    Regina L Agulto, Melissa M Rogers ... Kassandra M Ori-McKenney
    Doublecortin-like kinase 1 modulates its own kinase activity to tune its microtubule-binding affinity, providing molecular insights into a unique form of autoregulatory control over microtubule-binding activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules

    Thomas S McAlear, Susanne Bechstedt
    Demonstration of the biochemical capacity of the spindle protein CKAP2 as the most potent assembly factor of microtubules.
    1. Cell Biology

    Reconstitution of dynein transport to the microtubule plus end by kinesin

    Anthony J Roberts, Brian S Goodman, Samara L Reck-Peterson
    In vitro reconstitution reveals how a system of molecules works together to transport the motor protein dynein to the start of its track.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Effect of α-tubulin acetylation on the doublet microtubule structure

    Shun Kai Yang, Shintaroh Kubo ... Khanh Huy Bui
    Cryo-EM studies of doublet microtubules from wild-type and acetylation mutants suggest that acetylation of K40 affects the lateral rotational angle between protofilaments, leading to changes in the structure and stability.
    1. Cell Biology
    2. Neuroscience

    Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

    Liu He, Robbelien Kooistra ... Martin Harterink
    UNC119 complexes the microtubule binding CRMP to the cortical Ankyrin to immobilize the microtubule cytoskeleton in Caenorhabditis elegans neurons.
    1. Cell Biology
    2. Developmental Biology

    TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

    Katelyn J Hoff, Jayne E Aiken ... Jeffrey K Moore
    The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani, Sithara S Wijeratne, Radhika Subramanian
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.
    1. Cell Biology
    2. Developmental Biology

    DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair

    Marian Chuang, Tiffany I Hsiao ... Andrew D Chisholm
    Genetic suppressor screens with C. elegans reveal a novel function for the Death Associated Protein Kinase in regulation of epithelial microtubule dynamics.

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