1,341 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

    Elisabeth A Geyer, Alexander Burns ... Luke M Rice
    A buried mutation in αβ-tubulin reveals an allosteric response to GDP in the lattice that dictates microtubule catastrophe and shrinking.
    1. Cell Biology
    2. Developmental Biology

    Quantitative mapping of dense microtubule arrays in mammalian neurons

    Eugene A Katrukha, Daphne Jurriens ... Lukas C Kapitein
    Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.
    1. Physics of Living Systems

    Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

    Rachel A Banks, Vahe Galstyan ... Rob Phillips
    Mesoscopic properties of motor-microtubule assemblies, such as contractile rates and length scales, can be quantitatively connected to single-motor properties of kinesin motors.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

    Doudou Wang, Ryo Nitta ... Nobutaka Hirokawa
    The structural and functional analysis demonstrates the mechanism of dual functional, motility and microtubule depolymerization in a unique motor, KIF19A.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex

    Shinya Taguchi, Juri Nakano ... Ryo Nitta
    Structural, functional, and genetic analyses reveal how kinesin-4 motor KLP-12 precisely modulates the curvature of the microtubule plus-end to inhibit the microtubule dynamics for achieving the proper length control of axons.
    1. Physics of Living Systems

    Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

    Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
    Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Microtubules soften due to cross-sectional flattening

    Edvin Memet, Feodor Hilitski ... L Mahadevan
    A combination of experiments, theory, and simulations shows that the elastic softening of microtubules when they are bent arises due to the flattening of their tubular cross-section.
    1. Cell Biology

    Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

    Charlotte Guyomar, Clément Bousquet ... Denis Chrétien
    Tubulin engages unique lateral interactions without longitudinal ones during microtubule polymerization, leaving holes of a few subunits size potentially at the origin of tubulin exchange within their shaft.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz, Sarah Munyoki ... Luke M Rice
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Cell Biology

    Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

    Manuel Lera-Ramirez, François J Nédélec, Phong T Tran
    A simple mechanism relying on microtubule rescues occurring at midzone edges allows fission yeast spindles to elongate during anaphase B while maintaining microtubule overlaps, without the need to precisely regulate microtubule growth speed.

Refine your results by:

Type
Research categories