Kira Delmore, Juan Carlos Illera ... Miriam Liedvogel
Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
Hamdah Shafqat-Abbasi, Jacob M Kowalewski ... Staffan Strömblad
“Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
Smrithi Prem, Bharati Dev ... Emanuel DiCicco-Bloom
Alterations in mTOR signaling drive similar dysregulations in the critical mid-fetal neurodevelopmental processes of neurite outgrowth and cell migration in two distinct subsets of autism, idiopathic and 16p11.2 deletion.
William Duncan Martinson, Rebecca McLennan ... Philip K Maini
Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
Piezo1 activity within keratinocytes slows healing of wounded skin via dynamic channel enrichment at regions of the wound edge, causing localized retraction and thus hindering keratinocyte migration during wound healing.
Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
Erich R Eberts, Christopher G Guglielmo, Kenneth C Welch Jr
Ruby-throated hummingbirds switch from using torpor to survive nighttime energy emergencies in the breeding season to using it to spare fat stores and gain premigratory mass in the late summer.
Kristin M Sherrard, Maureen Cetera, Sally Horne-Badovinac
Stress fibers with multiple adhesions along their lengths and treadmilling dynamics may help migrating epithelial cells maintain a linear trajectory and thereby reinforce their collective motility.
At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.