5,123 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history and genomics of European blackcap migration

    Kira Delmore, Juan Carlos Illera ... Miriam Liedvogel
    Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
    1. Cell Biology
    2. Computational and Systems Biology

    An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

    Hamdah Shafqat-Abbasi, Jacob M Kowalewski ... Staffan Strömblad
    “Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
    1. Developmental Biology
    2. Neuroscience

    Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells

    Smrithi Prem, Bharati Dev ... Emanuel DiCicco-Bloom
    Alterations in mTOR signaling drive similar dysregulations in the critical mid-fetal neurodevelopmental processes of neurite outgrowth and cell migration in two distinct subsets of autism, idiopathic and 16p11.2 deletion.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

    William Duncan Martinson, Rebecca McLennan ... Philip K Maini
    Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

    Jesse R Holt, Wei-Zheng Zeng ... Medha M Pathak
    Piezo1 activity within keratinocytes slows healing of wounded skin via dynamic channel enrichment at regions of the wound edge, causing localized retraction and thus hindering keratinocyte migration during wound healing.
    1. Cell Biology
    2. Physics of Living Systems

    Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

    Kotryna Vaidžiulytė, Anne-Sophie Macé ... Mathieu Coppey
    Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Ecology
    2. Evolutionary Biology

    Reversal of the adipostat control of torpor during migration in hummingbirds

    Erich R Eberts, Christopher G Guglielmo, Kenneth C Welch Jr
    Ruby-throated hummingbirds switch from using torpor to survive nighttime energy emergencies in the breeding season to using it to spare fat stores and gain premigratory mass in the late summer.
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    1. Cell Biology
    2. Developmental Biology

    DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila

    Kristin M Sherrard, Maureen Cetera, Sally Horne-Badovinac
    Stress fibers with multiple adhesions along their lengths and treadmilling dynamics may help migrating epithelial cells maintain a linear trajectory and thereby reinforce their collective motility.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali, Navrita Mathiah ... Isabelle Migeotte
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.

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