296 results found
    1. Cell Biology
    2. Developmental Biology

    miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

    Eleonora Franzoni, Sam A Booker ... F Gregory Wulczyn
    The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
    1. Developmental Biology

    LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus

    Qinbo Zhou, Bo Yu ... Shusheng Wang
    lncEGFL7OS is a lncRNA located at the EGFL7/miR-126 locus that is critical for angiogenesis in humans.
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey, Sakshi Bansal ... Geetanjali Chawla
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Developmental Biology
    2. Genetics and Genomics

    miR-124 controls male reproductive success in Drosophila

    Ruifen Weng, Jacqueline SR Chin ... Stephen M Cohen
    A small RNA molecule called miR-124 controls pheromone production and sexual behaviour in Drosophila by regulating sex-specific gene expression in males.
    1. Developmental Biology
    2. Neuroscience

    MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

    Wei Zhang, Paul Jong Kim ... Li Zeng
    During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
    1. Computational and Systems Biology
    2. Medicine

    Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Dimitrios Chantzichristos, Per-Arne Svensson ... Gudmundur Johannsson
    A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
    1. Immunology and Inflammation

    MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

    Hui Xu, Shi-Jun Xu ... Liang-Hu Qu
    The liver-specific miRNA microRNA-122 plays a previously unknown role in hepatocyte intrinsic innate immunity by targeting the RTKs/STAT3 signaling pathway.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

    Morayma M Temoche-Diaz, Matthew J Shurtleff ... Randy Schekman
    Biochemical fractionation of vesicle sub-populations and in vitro reconstitution studies reveal that Lupus La protein mediates the selective sorting of miR-122 into extracellular vesicles in vitro and in vivo.
    1. Neuroscience

    MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice

    Reetu Daswani, Carlotta Gilardi ... Gerhard Schratt
    A new molecular mechanism involving microRNA, which controls synaptic transmission in a specialized type of inhibitory interneurons in the hippocampus and short-term memory in mice, was identified.
    1. Cancer Biology

    Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

    Xuefei Yan, Beibei Tang ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.

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