156 results found
    1. Cancer Biology

    miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

    Lihua Wang, Ergang Wang ... Xiling Shen
    miR-34a prevents inflammation-induced colonic regeneration from oncogenesis by simultaneously targeting processes in both immune and epithelial cells, including T helper 17 cell differentiation, recruitment, and IL-17 induced epithelial proliferation.
    1. Cancer Biology

    Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

    Xuefei Yan, Beibei Tang ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

    Lihua Wang, Pengcheng Bu ... Xiling Shen
    A novel long non-coding RNA targets microRNA miR-34a for epigenetic silencing and initiates asymmetric division of colon cancer stem cells.
    1. Cancer Biology

    Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

    Jia Li, Matthew Lam, Reproducibility Project: Cancer Biology
    1. Developmental Biology
    2. Neuroscience

    MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs

    Shih-Hsin Chang, Yi-Ching Su ... Jun-An Chen
    The miR-34/449 family is abundantly expressed in the central nervous system, and fine-tunes optimal numbers of spinal interneurons to ensure sensory-motor circuit outputs.
    1. Cell Biology

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M Nassal, Xiaoping Wan ... Isabelle Deschênes
    The ion channel accessory subunit KChIP2 has a transcriptional role that provides regulation over miRNA targets, driving the adverse remodeling of key ion channels during cardiac stress and leading to the development of arrhythmia.
    1. Computational and Systems Biology

    Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

    Zhuang Liu, Letian Zhang ... Ning Xu Landén
    A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.
    1. Cancer Biology
    2. Medicine

    Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

    Huan-Huan Chen, Tie-Ning Zhang ... Tao Zhang
    Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.
    1. Cell Biology
    2. Medicine

    Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

    Sharon Elliot, Paola Catanuto ... Marilyn K Glassberg
    A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.
    1. Cell Biology
    2. Developmental Biology

    Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

    Peter Walentek, Ian K Quigley ... Richard M Harland
    At optimal concentrations, the ciliary inhibitor Cp110 promotes ciliogenesis by localization to previously uncharacterized sites at the basal body, where it recruits ciliary adhesion complexes that mediate basal body interaction with F-actin networks.

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