1,277 results found
    1. Medicine

    Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

    Mieradilijiang Abudupataer, Shichao Zhu ... Weijia Zhang
    An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Contingency and selection in mitochondrial genome dynamics

    Christopher J Nunn, Sidhartha Goyal
    Single-molecule sequencing and mating experiments in yeast reveal key properties of mitochondrial DNA dynamics that inform the fate of mutant mtDNA in cells.
    1. Cell Biology
    2. Neuroscience

    Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

    Georgina Kontou, Pantelis Antonoudiou ... Josef T Kittler
    Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.
    1. Cell Biology
    2. Neuroscience

    Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

    Wei-Hua Lee, Hitoshi Higuchi ... Akihiro Ikeda
    The murine protein TMEM135 is a critical link between aging and age-dependent diseases.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection

    Bryan L Gitschlag, Ann T Tate, Maulik R Patel
    Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
    1. Cell Biology

    Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

    Wei-ke Ji, Anna L Hatch ... Henry N Higgs
    A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston, Joerg P Burgstaller ... Nick S Jones
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Genetics and Genomics

    Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

    Yue Zhang, Anne Lanjuin ... William B Mair
    Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.
    1. Cell Biology

    A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

    Robinson Arce-Molina, Francisca Cortés-Molina ... Alejandro San Martín
    A user-friendly genetically-encoded fluorescent sensor of improved dynamic range is introduced to facilitate the study of mitochondrial metabolism and diversity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A subcellular map of the human kinome

    Haitao Zhang, Xiaolei Cao ... Bin Zhao
    An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.

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