200 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Ji-Eun Lee, Chaochen Wang ... Kai Ge
    MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.
    1. Cancer Biology

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
    1. Cancer Biology

    Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

    Hao Zhang, Yang Zhang ... Chunliang Li
    The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

    William F Richter, Rohan N Shah, Alexander J Ruthenburg
    FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
    1. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt, Qinyu Zhang ... Konstantinos Anastassiadis
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina, Karin Schuster-Gossler ... Achim Gossler
    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

    Satoshi Takahashi, Akinori Kanai ... Akihiko Yokoyama
    Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani, Jingwen Song ... Stéphane Richard
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Developmental Biology

    Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

    Stanislao Igor Travisano, Vera Lucia Oliveira ... José Luis de la Pompa
    Notch ligands Jag1 and Dll4 and their effector Ephb2 are required in sinus venosus endocardium for primitive coronary vasculature formation and later for arterial differentiation and maturation of coronary endothelium.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

    Chintan K Kikani, Xiaoying Wu ... Jared Rutter
    PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.

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