13,632 results found
    1. Neuroscience

    How biological attention mechanisms improve task performance in a large-scale visual system model

    Grace W Lindsay, Kenneth D Miller
    Implementing neural changes associated with attention in a deep neural network causes performance changes that mimic those observed in humans and macaques.
    1. Developmental Biology
    2. Neuroscience

    Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

    Sergi Llambrich, Birger Tielemans ... Greetje Vande Velde
    Ts65dn mice exhibit structural, functional, molecular, and genetic alterations that are modulated but unrecovered by prenatal chronic GTE-EGCG, highlighting the importance of holistic studies to understand complex disorders and treatments.
    1. Developmental Biology
    2. Genetics and Genomics

    Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta

    David S Booth, Nicole King
    Genome editing in the choanoflagellate Salpingoeca rosetta opens newfound possibilities to functionally probe choanoflagellate genes that may illuminate the origin of their closest relatives, the animals.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil

    Rachel Lowe, Caio AS Coelho ... Xavier Rodó
    The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics.
    1. Computational and Systems Biology
    2. Neuroscience

    A quantitative model of conserved macroscopic dynamics predicts future motor commands

    Connor Brennan, Alexander Proekt
    Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Molecular mechanisms of microbiome modulation by the eukaryotic secondary metabolite azelaic acid

    Ahmed A Shibl, Michael A Ochsenkühn ... Shady A Amin
    Characterization of the molecular mechanisms that enable azelaic acid, a secondary metabolite produced by photosynthetic organisms, to promote or inhibit different bacterial populations.
    1. Neuroscience

    Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy

    Huasheng Yu, Jingwei Xiong ... Wenqin Luo
    Scratch-AID, a deep learning-based system for automatic quantification of mouse scratching behavior, could replace labor-intensive manual quantification and facilitate high through-put anti-itch drug screening.
    1. Ecology
    2. Microbiology and Infectious Disease

    A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system

    Jessica L Metcalf, Laura Wegener Parfrey ... Rob Knight
    High-throughput sequencing has been used to analyze the microbiome of mouse corpses over a period of 48 days, and to provide an accurate estimate of the time since death.
    1. Neuroscience

    Different brain systems support learning from received and avoided pain during human pain-avoidance learning

    Marieke Jepma, Mathieu Roy ... Albert Dahan
    Pharmacological fMRI study provides evidence that learning from the unexpected presence and absence of pain is mediated by different brain systems.
    1. Computational and Systems Biology
    2. Neuroscience

    Model discovery to link neural activity to behavioral tasks

    Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
    Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.

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