9,473 results found
    1. Cancer Biology
    2. Neuroscience

    Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain

    Mitul Desai, Jitendra Sharma ... Alan Jasanoff
    A vasoactive molecular imaging probe provides capability for sensitive functional imaging of cancer-associated protease activity in vivo.
    1. Chromosomes and Gene Expression

    Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes

    Yanxiang Ni, Bo Cao ... Hanben Niu
    Molecular beacon based FISH shows the capability of visualizing a 2.5 kb non-repetitive genomic DNA sequence in situ in human or mouse nuclear genome at super resolution.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

    Lukas Ded, Jae Yeon Hwang ... Jean-Ju Chung
    Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted photoactivation (PAPA)

    Thomas GW Graham, John Joseph Ferrie ... Xavier Darzacq
    Proximity-assisted photoactivation (PAPA) provides a new way to detect protein–protein interactions in single-molecule imaging of live cells.
    1. Developmental Biology

    Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining

    Wentao Yu, Lei Kang ... Terence TW Wong
    TRUST, as a rapid and fully automated whole-organ imaging technique, enables high-resolution multicolor 3D imaging at low cost by using a UV-LED for widefield illumination and a color camera while relieving researchers from lengthy and laborious tissue processing protocols.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek, Julius Fürsch ... Florian Stengel
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto, Akiko Yamazoe-Umemoto ... Koutarou D Kimura
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann, Olya Stringfield ... Hugo JWL Aerts
    Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Sperm: The secrets of success

    Kayla M Komondor, Anne E Carlson
    Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level.
    Insight
    Formats available:
    • HTML
    • PDF

Refine your results by:

Type
Research categories