883 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

    Alexis B Webb, Iván M Lengyel ... Andrew C Oates
    Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
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    1. Physics of Living Systems

    Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock

    Paul Gerald Layague Sanchez, Victoria Mochulska ... Alexander Aulehla
    A microfluidic experimental approach combined with dynamical systems theory reveals how to entrain an embryonic oscillator, the segmentation clock, and allows for the quantification of its entrainment properties.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit, Zhiyue Lu ... Arvind Murugan
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronization of oscillatory growth prepares fungal hyphae for fusion

    Valentin Wernet, Marius Kriegler ... Reinhard Fischer
    Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolving a 24-hr oscillator in budding yeast

    Gregg A Wildenberg, Andrew W Murray
    New complex traits can evolve through the elimination of genes in multiple unrelated pathways, rather than through the creation of new gene functions.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips, Cerys S Manning ... Nancy Papalopulu
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Computational and Systems Biology
    2. Developmental Biology

    A balance of positive and negative regulators determines the pace of the segmentation clock

    Guy Wiedermann, Robert Alexander Bone ... J Kim Dale
    Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.
    1. Genetics and Genomics
    2. Neuroscience

    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

    Renske Erion, Anna N King ... Amita Sehgal
    Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    NF-κB oscillations translate into functionally related patterns of gene expression

    Samuel Zambrano, Ilario De Toma ... Alessandra Agresti
    NF-κB oscillations synchronize to external perturbations as a damped oscillator, producing different transcription dynamics.

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