488 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular tweezer antagonizes seminal amyloids and HIV infection

    Edina Lump, Laura M Castellano ... Jan Münch
    CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.
    1. Structural Biology and Molecular Biophysics

    Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

    Seoyoon Kim, Daehyo Lee ... Duyoung Min
    An exceedingly low speed limit was estimated for a helical hairpin formation by analyzing hours-long, incessant structural transitions.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding, Henry Louis Schreiber IV ... Edward H Egelman
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Physics of Living Systems
    2. Developmental Biology

    Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

    Tae-Jin Kim, Chirlmin Joo ... Yingxiao Wang
    Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.
    1. Structural Biology and Molecular Biophysics

    Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

    My-Tra Le, Wojciech K Kasprzak ... Anne E Simon
    Folding and unfolding pathways are described for a ribosome-binding 3' cap-independent translation enhancer at the center of a conformational rearrangement that is implicated in the transition from translation to replication of an RNA virus.
    1. Biochemistry and Chemical Biology

    Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function

    Jason C Bell, Bian Liu, Stephen C Kowalczykowski
    Individual SSB-ssDNA complexes undergo reversible condensation and de-condensation that is modulated by RecOR during recombination.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

    Junyi Jiao, Mengze He ... Yongli Zhang
    Sec1/Munc18-family proteins chaperone SNARE assembly via a common templating mechanism.
    1. Cell Biology

    Caveolae couple mechanical stress to integrin recycling and activation

    Fidel-Nicolás Lolo, Dácil María Pavón ... Miguel A del Pozo
    Caveolae regulate integrin mechanosensing by establishing a force threshold for activation and recycling.
    1. Chromosomes and Gene Expression

    High-resolution, genome-wide mapping of positive supercoiling in chromosomes

    Monica S Guo, Ryo Kawamura ... Michael T Laub
    GapR-seq enables the global mapping of positive supercoiling in bacteria and yeast, revealing positive supercoils downstream of highly expressed genes and, in yeast, associated with centromeres, pericentromeres, telomeres, replication origins, and R-loops.

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