711 results found
    1. Computational and Systems Biology

    How the insect central complex could coordinate multimodal navigation

    Xuelong Sun, Shigang Yue, Michael Mangan
    The copy-and-shift mechanism modelled in the insect central complex facilitates multimodal navigation, providing a general computation model explaining flexible navigation behaviours.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes

    Joan Comenge, Jack Sharkey ... Antonius Plagge
    Combined cell labelling with a bi-cistronic reporter-gene vector and gold nanorods enables short- and long-term cell tracking in vivo via multimodal imaging (multispectral optoacoustic tomography, bioluminescence, fluorescence) with high spatial resolution.
    1. Neuroscience

    Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

    Nathaniel J Himmel, Akira Sakurai ... Daniel N Cox
    Anoctamin/TMEM16 and SLC12 co-transporter genes selectively function in regulating cold nociception via excitatory chloride currents and can promote neuropathic sensitization phenotypes, including behavioral sensitization and neuronal hyperexcitability in Drosophila multimodal sensory neurons.
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
    SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
    1. Neuroscience

    THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

    Martin N Hebart, Oliver Contier ... Chris I Baker
    THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.
    1. Neuroscience

    Brain structure and function link to variation in biobehavioral dimensions across the psychopathological continuum

    Jasper van Oort, Alberto Llera ... Philip FP van Eijndhoven
    The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.
    1. Neuroscience

    Multimodal sensory integration in single cerebellar granule cells in vivo

    Taro Ishikawa, Misa Shimuta, Michael Häusser
    Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Improving oligo-conjugated antibody signal in multimodal single-cell analysis

    Terkild B Buus, Alberto Herrera ... Sergei B Koralov
    Oligo-conjugated antibodies are a powerful tool but require thorough optimization to reduce background signal, increase sensitivity, and reduce sequencing costs.
    1. Neuroscience

    Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

    Meiqi Niu, Daniele Impieri ... Karl Zilles
    The macaque monkey intraparietal sulcus encompasses 17 cyto- and receptorarchitectonically distinct areas, which can be grouped into three clusters based on (dis)similarities of their molecular structure.
    1. Medicine
    2. Neuroscience

    Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study

    Peter R Millar, Brian A Gordon ... Beau M Ances
    Machine learning-based models of brain age using distinct MRI modalities (structural MRI and functional connectivity) capture complementary signals related to healthy age differences and capture unique patterns related to Alzheimer disease, including stages of disease progression, biomarkers, and cognition.

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