11 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing

    Perunthottathu K Umasankar, Li Ma ... Linton M Traub
    The muniscin protein FCHO1 interacts with, and activates, the adapter protein-2 complex (AP-2) to promote the assembly of clathrin-coated vesicles.
    1. Cell Biology

    NECAPs are negative regulators of the AP2 clathrin adaptor complex

    Gwendolyn M Beacham, Edward A Partlow ... Gunther Hollopeter
    Endocytosis is regulated by a protein family that recycles the AP2 clathrin adaptor by restoring the inactive form of complex.
    1. Cell Biology
    2. Evolutionary Biology

    Characterization of TSET, an ancient and widespread membrane trafficking complex

    Jennifer Hirst, Alexander Schlacht ... Margaret S Robinson
    A missing link between the AP complexes and COPI sheds light on the evolution of vesicle coat proteins and trafficking pathways in the earliest eukaryotes.
    1. Cell Biology
    2. Medicine

    Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

    Weili Fu, Sijie Chen ... Xuegong Zhang
    A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
    1. Cell Biology
    2. Evolutionary Biology

    Vesicle Coat Proteins: Finding the missing link

    Thomas U Schwartz
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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow, Richard W Baker ... Gunther Hollopeter
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei, Hao Sun ... Ling Qin
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Ecology

    Substantial near-infrared radiation-driven photosynthesis of chlorophyll f-containing cyanobacteria in a natural habitat

    Michael Kühl, Erik Trampe ... Klaus Koren
    Cyanobacteria with chlorophyll f show substantial near-infrared radiation-driven photosynthesis and can play an important role for primary production in endolithic, intertidal habitats.
    1. Medicine
    2. Physics of Living Systems

    High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice

    Anand O Masson, Bryce Besler ... Roman J Krawetz
    The method presented here allows researchers to retrieve accurate and reproducible biomechanical properties of mouse cartilage.
    1. Medicine

    Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

    Qi Sun, Gehua Zhen ... Xu Cao
    Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.

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